The observation that TNF-α is elevated in individuals with advanced heart failure (HF) prompted several high-profile clinical trials investigating whether TNF inhibitors could be used to treat HF. The failure of these trials and reports of RA patients treated with TNF inhibitors developing new-onset or worsening HF has raised questions as to whether TNF inhibition is beneficial or detrimental to the myocardium.

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Do TNF Inhibitors Increase the Risk of Heart Failure in Rheumatoid Arthritis?

Large scale, independent studies of glucosamine and/or chondroitin have not shown a definitive benefit for the treatment of painful knee osteoarthritis (OA) and the effect of retarding knee OA progression remains controversial.

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Is Glucosamine Sulfate an Effective Treatment for Osteoarthritis of the Hip?

Susceptibility to rheumatoid arthritis (RA) is complex; although a number of genetic susceptibility loci have been identified that appear to confer increased risk.

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European Admixture Associated with Genetic Risk for Rheumatoid Arthritis in African-Americans