Knee pain from osteoarthritis (OA) tends to be poorly correlated to degree of cartilage loss. Other factors related to knee OA, including bone marrow edema and synovitis, may be more proximal determinants of pain in knee OA. Synovitis is usually quite limited in knee OA and difficult to quantify on physical exam.

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Knee Pain from Osteoarthritis May be Related More to Change in Synovitis than Change in Cartilage

Both genetic and environmental exposures, to varying degrees, are felt to contribute to the risk and severity of systemic autoimmune diseases (e.g. rheumatoid arthritis (RA), lupus, etc…)

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Do Occupational Exposures Increase the Risk of Death from Systemic Autoimmune Disease?

Video from the 2007 JHU Rheumatology Pathophysiology lectures at Johns Hopkins University.

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2007 Rheumatology Pathophysiology Lectures

Videos from the Maryland Arthritis Foundation annual 2007 Topics in Clinical Rheumatology symposium.

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2007 Topics in Clinical Rheumatology