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RA is associated with an increase in cardiovascular (CV) events, such as myocardial infarction (MI) and sudden cardiac death. Inflammatory cytokines, such as TNF-α, are implicated in atherothrombosis and the RA disease state, potentially explaining the increased risk of CV events in RA. The use of TNF inhibitors was associated with a reduced risk of cardiovascular events in RA patients in one study, although it is not clear whether these effects are due to unique features of TNF inhibitors or are a consequence of non-specific suppression of inflammation. Here, Dixon et al (Arthritis Rheum 2007; 56(9): 2905) explore these issues in analyses of participants enrolled in the British Society for Rheumatology Biologics Register (BSRBR).
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Is TNF Inhibitor Use Associated with a Reduced Risk of Myocardial Infarction in Rheumatoid Arthritis?
RA is associated with an increase in cardiovascular (CV) events, such as myocardial infarction (MI) and sudden cardiac death. Inflammatory cytokines, such as TNF-α, are implicated in atherothrombosis and the RA disease state, potentially explaining the increased risk of CV events in RA. The use of TNF inhibitors was associated with a reduced risk of cardiovascular events in RA patients in one study, although it is not clear whether these effects are due to unique features of TNF inhibitors or are a consequence of non-specific suppression of inflammation. Here, Dixon et al (Arthritis Rheum 2007; 56(9): 2905) explore these issues in analyses of participants enrolled in the British Society for Rheumatology Biologics Register (BSRBR).
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Is TNF Inhibitor Use Associated with a Reduced Risk of Myocardial Infarction in Rheumatoid Arthritis?
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The potential for hepatotoxicity is a well-recognized feature of therapy with a number of DMARDs in rheumatoid arthritis (RA), with methotrexate (MTX) being the most common utilized. Concomitant use of other hepatotoxic agents has the potential to compound the risk of significant liver damage. Among these, isoniazid (INH) is increasingly used in RA patients receiving MTX with evidence of latent tuberculosis infection (LTBI) or prior active tuberculosis for whom TNF inhibitor therapy is planned. Here, Mor et al (Ann Rhem Dis 2007 published online Aug 29) explore the safety of this combination of potentially hepatotoxic agents.
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Combination of Methotrexate and Isoniazid Appears Safe for RA Patients
The potential for hepatotoxicity is a well-recognized feature of therapy with a number of DMARDs in rheumatoid arthritis (RA), with methotrexate (MTX) being the most common utilized. Concomitant use of other hepatotoxic agents has the potential to compound the risk of significant liver damage. Among these, isoniazid (INH) is increasingly used in RA patients receiving MTX with evidence of latent tuberculosis infection (LTBI) or prior active tuberculosis for whom TNF inhibitor therapy is planned. Here, Mor et al (Ann Rhem Dis 2007 published online Aug 29) explore the safety of this combination of potentially hepatotoxic agents.
Original post:
Combination of Methotrexate and Isoniazid Appears Safe for RA Patients
An informational discussion on the potential issues with Knuckle Cracking related to Arthritis
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Knuckle Cracking and Arthritis
An informational discussion on the potential issues with Knuckle Cracking related to Arthritis
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Knuckle Cracking and Arthritis
